ProEncia was founded with a simple mission: to deliver a more effective treatment for patients who suffer from periodontal diseases.

While many forms of treatment exist on the market today, efficacy varies widely and periodontal disease remains a chronic, often-irreversible condition affecting over a billion people worldwide. There are many reasons for this, but chief among them is the complexity of periodontal disease, which creates many interlinked challenges for the development of new treatments.

ProEncia’s R&D approaches periodontal disease with this complexity in mind. Our patent-pending discovery platform utilizes the power of small molecule combination medicine to generate a multifold synergy in essential therapeutic effects - including antimicrobial properties, anti-inflammatory immune regulation, and system damage resolution and repair.

Our focus is centered on the idea of reaching system allostasis, with the intention to establish system homeostasis. We believe in the popular hypothesis that establishing balance in pro-active inflammatory and regulatory immune surveillance systems is crucial - both as part of innate and adaptive immune defense, and as a component of system survival against foreign threats and harmful internal processes.

This approach is based on a deep understanding of the multi-faceted nature of periodontal disease and oral health.

Understanding Periodontal Disease

It’s easy to oversimplify periodontal disease as a simple bacterial infection or tissue inflammation. But, the reality is that the etiology of periodontal disease is complex, and understanding this is crucial when approaching treatment.

It commences with daily exposure to pathogenic bacteria, their colonization around the gumline, and the onset of gingivitis. The disease's continued advancement is marked by the persistent activity of pathogen-derived pro-inflammatory enzymes and toxins on host tissue, the unregulated systemic response of host tissue factors, and compromised immune system responses. Ultimately, this leads to progressive systemic damage and the chronic destructive disease state known as periodontitis.

Dental researchers and clinicians have poured an immense amount of time and energy into finding new ways to treat periodontal disease. Despite this, the dental field still does not have a complete answer to the problem. Advanced chronic periodontal disease is often considered non-reversible, and carries with it a number of painful, degenerative, and debilitating symptoms. Most treatments today focus on managing symptoms to prevent further deterioration, and results are highly dependent on each patient’s individual health and disease progression.

Such treatments include non-invasive small-molecule abrasives (specialty toothpastes or mouthwashes), pharmaceutically-active antibiotics and anti-inflammatory drugs, and invasive procedures such as scaling and root planning (SRP), laser therapy (LNAP), gingival grafts, or periodontal plastic surgery (including implants, veneers, and the like) to prevent and repair bone, tissue, and cosmetic damage.

All of these treatments serve important functions in treatment. However, depending on the patient, they may leave components of the disease unaddressed.

The Dual Effects of the Oral Microbiome

In addition to the nature of the disease, it’s important to factor in that the mouth maintains a dynamic oral microbiome which is crucial to human health.

This microbiome is a homeostatic, balanced ecosystem of microbiota (beneficial probiotic bacteria, fungi, viruses) and oral biofilm like plaque, which forms naturally every day on the tongue, cheeks (mucosa), palate, gum and teeth surfaces - oftentimes encroaching on the gingival margin sulcus and pocket, on dental implants, and on veneers. 

Breakdown of this fragile balance can occur under harmful pathogen invasion and dysbiosis (excessive bacterial growth). This can be caused by stress, poor oral hygiene, age, poor health, and conditions such as immune system disorders. This can lead to pathogen infestation, accelerated periodontal plaque formation, and hardened tartar buildup. A serious consequence of this condition can be the onset of gingival infection and inflammation. 

This process and group of symptoms is the hallmark of advanced periodontal disease, as well as peri-implant diseases, dental cavity (carries, pyorrhea), and may even extend to broader adverse systemic health effects.

The importance of the oral microbiome is what makes oral hygiene and prevention work so crucial throughout one’s lifetime.

What Makes Good Oral Hygiene?

Most people think of good oral hygiene as simply brushing and flossing, combined with regular dental checkups. However, as we know from the prevalence of periodontal disease, this is often not enough. In an optimal setting, good oral hygiene would include the ability to handle the following events:

• Daily periodontal pathogen exposure and invasion

• Handling of supragingival and subgingival bacteria colonization

• Handling of released pro-inflammatory factors and toxins on host tissue

• Handling of surface symptoms. (bleeding, halitosis, sensitivity)

• Handling of acute and chronic inflammation

• Removal of excessive plaque and calculus buildup

• Repair and restoration of damaged host tissue and tissue integrity

• Handling of progressive deterioration from compromised host immune system activities. 

With this in mind, ProEncia products are designed to complement existing oral hygiene practices and enhance their ability to assist or interact with these functions, in order to achieve optimal oral hygiene. 

Periodontal Challenges

There are many challenges in addressing oral hygiene, the oral microbiome, and treating periodontal diseases. Some of the most prominent include:

• Preventing periodontal infection from predatory pathogens such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and the like

• Transformation of pathogen-infected periodontal cells and tissues acting as protective pathogen shields

• Altered immune tolerance and allostatic pro-inflammatory load overload-linked immune imbalances.

• Persistent tissue-destructive and dysregulated inflammatory mediator outbursts; and limited system regenerative repair and resolution
  

The ProEncia Platform

At ProEncia, we believe that proper treatment of periodontal disease relies on a deep understanding of periodontal disease etiology, the oral microbiome, and associated treatment challenges. This foundation serves as the best gateway to new, innovative care methodologies. 

The ProEncia R&D platform and its patent-pending product pipeline are designed prevent, protect, repair, and resolve periodontal diseases. The goal of this novel treatment is to establish allostasis and a remedial path towards achieving system homeostasis against harmful oral issues. 

Our products target remarkable therapeutic outcomes. They behave as system regulators via exploiting weakness in microbial survival mechanisms; manipulation of cell surface TLR (toll-like receptors) activity against microbial influence; favorable manipulation of pro-inflammatory immune response activity and its switch; and utilization of multifold synergy in the activity of small molecule combination medicine. This complements an essential therapeutic demand, acting as an antimicrobial, anti-inflammatory immune regulator to drive system damage repair and reversal.